我们课题组主要研究方向为纳米材料的可控合成及其生物效应研究。多年来一直从事新型多功能纳米材料的设计合成及其在生物成像,癌症治疗和纳米生物安全性的研究工作。以多功能纳米材料的设计合成为核心,以材料的功能化为导向,以癌症综合治疗为目的,开发出过渡金属离子掺杂、多重核壳纳米结构调控、质子插层等纳米材料制备新方法,构建了一系列具有特定功能的荧光上转换、过渡金属硫化物/硒化物、多酸纳米团簇等新型纳米粒子;针对生物纳米材料的客观需求,利用同步辐射、生物成像等手段系统研究了这些纳米粒子的生物分布、转化、代谢和清除过程,获取理化特性对其体内过程及生物安全性的影响规律;进一步地,利用纳米粒子独特的理化性质和多药物共输运能力,探索了纳米材料介导的热疗/化疗/放疗/光动力治疗等多模态协同治疗策略,揭示了纳米材料介导的不同治疗手段的协同增效机制,为优化纳米材料介导的肿瘤综合治疗提供了依据,同时也为临床优化肿瘤综合治疗策略提供了借鉴。


我的学术主页:

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Research Projects

1. Synthesis of one-dimensional nanostructures by developing new synthetic approaches. Development of upconversion nanoparticle derived multifunctional materials for bioimaging, sensor and drug delivery.


2.   Mutilfunctional nanomaterials for in vitro and in vivo bio-imaging.

3.   Smart responsive nanocarriers and nanodrug.

4.   Mutilfunctional nanomaterials for combination therapy.




基于我们课题组研究工作的一些综述文章

主题#1:X射线响应的纳米材料用于肿瘤放疗增敏或放疗防护

  • Emerging Strategies of Nanomaterial-Mediated Tumor Radiosensitization. Advanced Materials 2019,31, 1802244.

  • Harnessing Tumor Microenvironment for Nanoparticle-Mediated Radiotherapy. Advanced Therapeutics 2018, 1, 1800050.

  • Strategies based on metal-based nanoparticles for hypoxic-tumor radiotherapy. Chemical Science 2019, 10, 6932-6943.

  • 多功能纳米材料在肿瘤放疗增敏中的应用. 物理化学学报 2018, 34, 140-167.

主题#2:近红外光响应的纳米生物材料的设计与诊疗应用

  • Graphene-Based Smart Platforms for Combined Cancer Therapy. Advanced Materials 2019, 31, 1800662.

  • Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy. Advanced Materials 2015, 27, 7692.

  • Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications. Advanced Materials 2013, 25, 3758-3779.

  • Two-dimensional transition metal dichalcogenide nanomaterials for combination cancer therapy. Journal of Materials Chemistry B 2017, 5, 1873-1895.

  • Recent advances of stimuli-responsive systems based on transition metal dichalcogenides for smart cancer therapy. Journal of Materials Chemistry B 2019, 7, 2588-2607.

  • Design, Synthesis, and Surface Modification of Materials Based on Transition-Metal Dichalcogenides for Biomedical Applications. Small Methods 2017, 1, 1700220.

  • Transition Metal Dichalcogenides for Biomedical Applications. In Two Dimensional Transition Metal Dichalcogenides: Synthesis, Properties, and Applications; Arul, N. S., Nithya, V. D., Eds.; Springer Singapore: Singapore, 2019; pp 241-292. (书籍章节)

主题#3:NO或CO等气体控释体系的构筑与肿瘤治疗或伤口抗菌应用

  • Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials. Small 2019, 15, 1904382.

  • Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives. Theranostics 2020, 10, 757-781.

主题#4:纳米生物效应+纳米毒理学+纳米生物医学

  • Precise nanomedicine for intelligent therapy of cancer. Science China Chemistry 2018, 61, 1503-1552.

  • A Safe-by-Design Strategy towards Safer Nanomaterials in Nanomedicines. Advanced Materials 2019, 31, 1805391.

  • Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue. Advanced Science 2019, 6, 1802289.

  • Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species. Chemistry – An Asian Journal 2013, 8, 2342-2353.

  • Nanotoxicity of Near Infrared Nanomaterials. In Near-infrared Nanomaterials: Preparation, Bioimaging and Therapy Applications; The Royal Society of Chemistry, 2016; pp 355-402. (书籍章节)