Zhanjun Gu Group

祝贺谢佳妮同学在ACS Appl. Mater. Interfaces 发表学术论文

2017-04-06 20:19Views:77times


TitleTherapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells

AbstractThe low water solubility, extensive metabolism and drug resistance are still the unavoidable defects in biomedical applications for insoluble drug of curcumin. Herein, we employed a D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) functionalized NIR-triggered photothermal mesoporous nanocarriers bamboo charcoal nanoparticles (TPGS-BCNPs) to load and deliver curcumin for improving its bioavailability. This system could considerably increase the accumulation of curcumin in cancer cells for curcumin bioavailability enhancement via simultaneously promoting the cellular internalization of the as-synthesized composite (TPGS-BCNPs@Curcumin) by the size effect of NPs and considerably triggering controlled curcumin release from TPGS-BCNPs@Curcumin by the NIR stimulation as well as reducing efflux of curcumin by the P-glycoprotein (P-gp) inhibition of TPGS, so as to enhance the therapeutic effect of curcumin and realize better chemo-photothermal synergetic therapy in vitro and in vivo. Besides cancer therapy, studies indicated that curcumin and some carbon materials could be used as radical scavengers that play an important role in radioprotection for normal cells. Hence we also investigated the free-radical-scavenging ability of TPGS-BCNPs@Curcumin composite in vitro to preliminarily evaluate its radioprotection ability for healthy tissue. Therefore, our work provided a multifunctional delivery system for curcumin bioavailability enhancement, chemo-photothermal synergetic therapy of cancer and radioprotection of healthy tissue.



CitationXie Jiani#, Yong Yuan#, Dong Xinghua, Du Jiangfeng, Guo Zhao, Gong Linji, Zhu Shuang, Tian Gan, Yu Shicang, Gu Zhanjun*, Zhao Yuliang. Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells. ACS Applied Materials & Interfaces. 2017. DOI: 10.1021/acsami.7b02622


AcknowledgmentsThis work was supported by the National Basic Research Programs of China (2016YFA0201600, 2016YFA0202104 and 2015CB932104), National Natural Science Foundation of China (No. 31571015, 11621505, 11435002 and 21320102003) and Youth Innovation Promotion Association CAS (2013007).