Zhanjun Gu Group

祝贺祖艳在RSC Advances 发表学术论文

2017-03-23 20:06Views:188times


TitleProtein-directed synthesis of Bi2S3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract

AbstractNon-invasive imaging modalities such as computed tomography are often used for diagnosis and assessment of gastrointestinal (GI) disease status over the long-term. The physiology of the GI tract can be assessed with contrast agents. Here, we present common protein (bovine serum albumin, BSA) stabilized bismuth sulfide nanoparticles with robust X-ray attenuation. Under the optimal conditions, this agent can outline the anatomy of the mouse GI tract on 3D computed tomography imaging, with the real-time and non-invasive visualization of nanoparticle distribution and the GI tract. Moreover, the investigation on long-term toxicity and biodistribution of these nanoparticles after oral administration indicate their overall safety. This is a promising agent for GI visualization and disease diagnosis.


CitationZu Yan#, Yong Yuan#, Zhang Xiao, Yu Jie, Dong Xinghua, Yin Wenyan, Yan Liang*, Zhao Feng, Gu Zhanjun, Zhao Yuliang. Protein-directed synthesis of Bi2S3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract. RSC Advances. 2017;7:17505-17513.DOI:10.1039/c7ra01526g


AcknowledgmentsThis work was supported by the National Natural Science Foundation of China (31600815, 11621505, 21320102003), Innovation Program of the Chinese Academy of Sciences (QYZDJ-SSW-SLH022) and Youth Innovation Promotion Association CAS (2013007).