祝贺余杰同学在Nanoscale 发表学术论文

Title: Biodistribution, Excretion, and Toxicity of Polyethyleneimine Modified NaYF4:Yb,Er Upconversion Nanoparticles in Mice via Different Administration Routes

Abstract: Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we choose polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles (abbreviated as PEI@UCNPs) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation in the spleen within 30 days. Comparably, PEI@UCNPs via i.g. administration changed and decreased with time in various body tissues and were found mainly in ileum and cecum but rather low in the other examined organs. For the i.v. injected group, the UCNPs exhibited an obvious clearance from body within 30 days and the accumulation in the spleen gradually decreased. Furthermore, 64Cu labeled PEI@UCNPs were i.v. injected for real time photon emission computed tomography (PET) imaging to further confirm the biodistribution in mice. Afterward, excretion routes of the PEI@UCNPs were evaluated. For i.p. injected groups, the UCNPs were slowly and partly excreted via feces and urine for 30 days, and a large amount of the UCNPs were steady excreted via feces for the i.v. group, suggesting that the UNCPs via i.v. injection can be potentially used for imaging and therapy studies in vivo. However, for i.g. administrated group, most of the UCNPs were excreted from feces within 48 h. Hematology, body weight, and biochemical analysis were used to further quantify the potential toxicity of the UCNPs, and results indicated that there was no over toxicity of the UCNPs in mice at the tested period. This work suggests the clearance and excretion capabilities of PEI@UCNPs are particularly depending on their administration routes.

Scheme 1. Schematic illustration of one-pot hydrothermal synthesis of PEI@UCNPs and their different administration routes by intraperitoneal injection (i.p.), intravenous injection (i.v.), and intragastric administration (i.g.) in mice.

Citation: Jie Yu^#,  Wenyan Yin^*,  Tao Peng,  Ya Nan Chang,  Yan Zu,  Juan Li,  Xiao He^*,  Xiaoyan Ma^*,  Zhanjun Gu^* and  Yuliang Zhao^*. Nanoscale, 2017, DOI: 10.1039/C7NR00078B‍

Acknowledgments: This work was supported by the National Basic Research Programs of China (2016YFA0201600, 2015CB932104), the Beijing Natural Science Foundation (2162046), the National Natural Science Foundation of China (11621505, 31571015, 51372206, and 21320102003), Innovation Program of the Chinese Academy of Sciences (QYZDJ-SSW-SLH022), and Doctorate Foundation of Northwestern Polytechnical University (CX201323).