Zhanjun Gu Group


2017-05-15 15:30Author:管理员Views:114times

Title:Design of TPGS functionalized Cu3BiS3nanocrystals with strong absorption in the second near-infrared window forradiation therapy enhancement

       TPGS-functionalized Cu3BiS3 nanocrystals with strong absorbanceof both X-ray and NIR light in the second NIR window were designed tosynergistically enhance the efficacy of radiation therapy through i) depositingmore irradiation energy; ii) overcoming the hypoxia-associatedradio-resistance; and iii) generating hydroxyl radical via the copper-catalyzedFenton-like and Haber-Weiss reaction.


       Integrating radiation therapy withhigh-depth photothermal therapy in the second near-infrared (NIR) window ishighly required for efficient treatment of the deep-seated tumor cells. Here,we constructed a multifunctional nano-theranostics with bimetallic chalcogenidenanocrystals (NCs) functionalized with amphiphilic D-α-tocopherol polyethyleneglycol 1000 succinate (TPGS-Cu3BiS3). Benefiting from the strong absorbance ofboth X-ray and NIR light in the second NIR window, TPGS-Cu3BiS3 CNs can notonly deposit more radiation dose to trigger enhanced radiation damage in vivo,but also conduct photo-induced hyperthermia for thermal ablation in the secondNIR window and effective improvement of tumor oxygenation to overcome thehypoxia-associated radio-resistance of tumors. Moreover, copper ions on thesurface of TPGS-Cu3BiS3 NCs are capable of catalyzing the Fenton-like andHaber-Weiss reactions to produce highly reactive hydroxyl radical, leading toincrease the level of oxygen radicals and further enhance cancer celldestruction. Apart from their therapeutic application, by means of X-raycomputer tomography imaging as well as multispectral optoacoustic tomographyimaging, TPGS-Cu3BiS3 NCs also have the potential as a nano-theranostics tooffer the remarkable therapeutic outcome for the deep-seated tumor cells in theimaging-guided synergistically enhanced radiation therapy.


       Jiangfeng Du#,Xiaopeng Zheng#, Yuan Yong, Jie Yu, Xinghua Dong, Chenyang Zhang,Ruyi Zhou, Bai Li, Liang Yan*, Chunying Chen*, Zhanjun Gu*,Yuliang Zhao. Design of TPGS-functionalized Cu3BiS3nanocrystals with strong absorption in the second near-infrared window forradiation therapy enhancement. Nanoscale 2017. doi: 10.1039/C7NR02213A


       This work was supported by the National BasicResearch Programs of China (2016YFA0201600, 2014CB931900 and 2015CB932104),National Natural Science Foundation of China (No. 31571015, 11621505, 11435002and 21320102003), Youth Innovation Promotion Association CAS (2013007) and Researchand Innovation Program for College Graduates of Jiangsu Province (KYLX15_1204).